ea0016p498 | Obesity | ECE2008
Ostertag Anke
, Herzig Stephan
Obesity, insulin resistance and high cholesterol levels are hallmarks of the metabolic syndrome. The molecular players involved in the onset of the metabolic syndrome are mostly unknown. In this context the three pseudokinases of the tribbles family have emerged as potential candidates. Among them, TRB3 has been described as a negative regulator of Akt, a key player in insulin signal transduction. However, the biological functions of TRB family members remain largely unknown. ...